Interactions / Warnings:
Interaction with alcohol is unknown. Please consult your doctor.
Pregnancy interaction:
Sirova 1mg Tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Expert advice:
You may be frequently monitored for renal function during concomitant administration of sirolimus and ciclosporin. Sirolimus increase risk of infection and the risk of developing certain types of cancer (e.g., lymphoma, skin cancer). Seek immediate medical attention if you notice signs of infection (e.g., persistent sore throat, chills, and fever), any changes in the appearance or size of a mole, night sweats, unusual growths or lumps, or unusual tiredness or weakness. Avoid use of live vaccines during treatment as the vaccination may be less effective when taking sirolimus. Use effective methods of contraception during sirolimus therapy and for 12 weeks after sirolimus has been stopped. Consult your doctor if you develop any liver problems, kidney problems, high cholesterol or triglycerides, low blood platelet levels, diabetes or high blood sugar, or lung or breathing problems or if you are considered to be at high risk for rejection, such as if you had a previous transplant that was lost to rejection. Limit the exposure to sunlight and UV light by covering your skin with clothing and using a sunscreen with a high protection factor because of the increased risk for skin cancer, when receiving sirolimus. Take sirolimus at the same time in relation to ciclosporin, and consistently with or without food, as its blood levels will be monitored.
Side Effects:
Nausea, Headache, Abdominal pain, Viral infection, Pneumonia, Low blood platelets, Increased heart rate, Decreased white blood cell count, Anemia (low number of red blood cells), Urinary tract infection, Diarrhoea, Increased blood pressure, Bacterial infection, Fungal infection, Constipation, Herpes virus infection.
How to use:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sirova 1mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How it works:
Sirova 1mg Tablet suppresses the activity of body's immune system and prevents rejection of the transplanted organ.
Faq for medicine:
Q: Is Sirova dialyzable?
A: Sirova is not dialyzable to significant extent. i.e. it will not be eliminated after dialysis.
Q: Is Sirova a calcineurin inhibitor?
A: Sirova is not a calcineurin inhibitor, but it has a similar suppressive effect on the immune system
Q: Is Sirova cytotoxic?
A: Sirova is a cytotoxic agent
Q: What is Sirova-eluting stent?
A: The Sirova-eluting stent is a metal stent coated with 140 µg/cm2 of Sirova blended with synthetic polymers. After stent implantation, Sirova is slowly released causing localized inhibition of growth of smooth muscle cells in the wall of the blood vessel in which it is implanted over a period of about 1 month
Q: Does Sirova cause hair loss?
A: Sirova causes hair loss
Q: Why does Sirova cause hyperlipidemia?
A: Sirova alters certain body pathways to increase lipid/fat synthesis by the liver, thereby causing hyperlipidemia.
Medicine interaction:
Sirova with Roxithromycin|Sirova with Clarithromycin|Sirova with Azithromycin|Sirova with Bacillus Calmette-Guerin high strength|Sirova with Bacillus Calmette-Guerin|Sirova with Rotavirus vaccine (live attenuated,oral)|Sirova with Rubella vaccine (Live)|Sirova with Voriconazole|Sirova with Erythromycin|Sirova with Varicella Vaccine (live) attenuated|Sirova with Spiramycin|Sirova with Inactivated Japanese Encephalitis virus protein|Sirova with Rifampicin|Sirova with Posaconazole|Sirova with Phenytoin|Sirova with Danazol|Sirova with Ritonavir|Sirova with Enalapril|Sirova with S-Amlodipine|Sirova with Benidipine|Sirova with Ramipril|Sirova with Lercanidipine|Sirova with Fosphenytoin|Sirova with Nimodipine|Sirova with Cilnidipine|Sirova with Itraconazole|Sirova with Nifedipine|Sirova with Carbamazepine|Sirova with Perindopril|Sirova with Amlodipine|Sirova with Fluconazole|Sirova with Ketoconazole
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